Investigating the mechanisms driving lower bowel symptoms in hypermobile EDS (hEDS)
Anisa Choudhary & Prof. Qasim Aziz, Wingate Institute of Neurogastroenterology, Blizard Institute, Queen Mary University of London.
Full study title: Characterisation and comparison of the symptoms and pathophysiological mechanisms underlying irritable bowel syndrome (IBS) with and without hypermobile Ehlers-Danlos syndrome (hEDS).
This research is aimed at understanding the underlying causes of gastrointestinal (GI) symptoms in hypermobile Ehlers-Danlos syndrome (hEDS). Researchers will look at rectal (back passage) hypersensitivity in patients with and without IBS/hEDS overlap to see if there is a difference between the two groups.
You may be eligible if the following criteria describe you:
- Female, aged between 18 and 65 years
- Have been told you have hypermobile Ehlers-Danlos syndrome (hEDS)
- Suffer from lower bowel symptoms such as abdominal pain, constipation and diarrhoea
- No previous abdominal or bowel surgery
- No history of inflammatory bowel disease (Crohn’s or ulcerative colitis)
Eligible participants will be invited for two separate study visits (approx. 6 hours in total) to have a series of short investigations that measure: sensation in the back passage, functioning of the nerves in the back passage and motility through the gut. Study visits will take place at either the Royal London Hospital, London or the Wingate Institute of Neurogastroenterology, Blizard Institute, Queen Mary University of London.
You will receive reimbursement for any travel expenses occurred as a result of participating in the study.
To find out more or ask about taking part, please contact the researcher.
Start date: 03/02/2020
Finish date: 31/03/2021
Should you have any queries about this study please use the details below: